Antibiotics from basidiomycetes. XXXVIII. 2-Methoxy-5-methyl-1,4-benzoquinone, a thromboxane A2 receptor antagonist from Lentinus adhaerens.
نویسندگان
چکیده
In the course of our screening for antithrombotic compounds using platelet rich plasma from bovine slaughter blood, 2-methoxy-5-methyl-1,4-benzoquinone (1) has been isolated from mycelial cultures of Lentinus adhaerens. The compound inhibits the U46619-induced aggregation of human blood platelets with an IC50 of 2.5 micrograms/ml (16.45 microM) and is a new thromboxane A2 receptor antagonist. This is the first report on an inhibitor of platelet aggregation derived from secondary metabolism of basidiomycetes.
منابع مشابه
The nature, intergeneric distribution and biosynthesis of isoprenoid quinones and phenols in gram-negative bacteria.
1. Twenty-two aerobically grown Gram-negative bacteria were analysed for demethylmenaquinones, menaquinones, 2-polyprenylphenols, 6-methoxy-2-polyprenylphenols and ubiquinones. 2. All the eight enterobacteria and both the two facultative organisms (Aeromonas punctata and Aeromonas hydrophila) examined contain all the compounds listed above. The principal homologues are octaprenyl; in addition l...
متن کاملLosartan and tempol treatments normalize the increased response to hydrogen peroxide in resistance arteries from hypertensive rats.
OBJECTIVE To analyse the role of angiotensin II, via AT1 receptors, and oxidative stress in the mechanisms underlying the increased response to hydrogen peroxide (H2O2) of mesenteric resistance arteries from spontaneously hypertensive rats (SHRs). METHODS Arteries from normotensive and SHRs untreated or treated with the AT1 receptor antagonist, losartan (15 mg/kg per day, 12 weeks), or with t...
متن کاملMechanisms of epidermal growth factor-induced contraction of guinea pig
We investigated the functional effects of epidermal growth factor (EGF) on guinea pig airways in vitro. EGF (3 ng/ml to 1 !-tg/ml) induced a concentration-dependent contraction in epithelium-denuded strips. The average of maximal contractions was 0.64±0.1 g (mean±S.E., for n=27), which was 72.0±9.5% of 100 mM KCI-induced contraction. The ECso was 12.3±1.6 ng/ml. The presence of epithelium signi...
متن کاملAdenosine diphosphate (ADP)–induced thromboxane A2 generation in human platelets requires coordinated signaling through integrin IIb 3 and ADP receptors
Adenosine diphosphate (ADP) is a platelet agonist that causes platelet shape change and aggregation as well as generation of thromboxane A2, another platelet agonist, through its effects on P2Y1, P2Y12, and P2X1 receptors. It is now reported that both 2-propylthio-D-dichloromethylene adenosine 5 -triphosphate (AR-C67085), a P2Y12 receptor–selective antagonist, and adenosine-2 -phosphate-5 -phos...
متن کاملHEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY Adenosine diphosphate (ADP)–induced thromboxane A2 generation in human platelets requires coordinated signaling through integrin IIb 3 and ADP receptors
Adenosine diphosphate (ADP) is a platelet agonist that causes platelet shape change and aggregation as well as generation of thromboxane A2, another platelet agonist, through its effects on P2Y1, P2Y12, and P2X1 receptors. It is now reported that both 2-propylthio-D-dichloromethylene adenosine 5 -triphosphate (AR-C67085), a P2Y12 receptor–selective antagonist, and adenosine-2 -phosphate-5 -phos...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- The Journal of antibiotics
دوره 44 1 شماره
صفحات -
تاریخ انتشار 1991